Bioinformatic analysis determined that the di-arginine motif is present in the first 25 residues in a large number of all ER/SR Gene Ontology (GO annotated proteins. Our data show that PLN is recycled via the retrograde Golgi to ER membrane traffic pathway involving COP-I vesicles, since co-immunoprecipitation assays determined that COP I interactions are dependent on an intact di-arginine motif as PLN RDelta14 did not co-precipitate with COP I containing vesicles. Here we were interested in determining the cellular mechanisms involved in this disease-causing mutation.Mutations deleting codons for either or both Arg13 or Arg14 resulted in the mislocalization of PLN from the ER. A mutation of PLN in which one of the di-arginine residues at positions 13 and 14 was deleted led to a severe, early onset dilated cardiomyopathy. In this study, we show that protein kinase C-induced TCR down.Įndoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?ĭirectory of Open Access Journals (Sweden)įull Text Available Phospholamban (PLN is an effective inhibitor of the sarco(endoplasmic reticulum Ca(2+-ATPase, which transports Ca(2+ into the SR lumen, leading to muscle relaxation. However, the role of the CD3γ diL motif in T-cell development is not known. In this study, we show that protein kinase C-induced TCR down-regulatio.The CD3γ di-leucine-based ( diL) receptor-sorting motif plays a central role in TCR down-regulation and in clonal expansion of virus-specific T cells. The CD3γ di-leucine-based ( diL) receptor-sorting motif plays a central role in TCR down-regulation and in clonal expansion of virus-specific T cells. Lauritsen, Jens Peter Holst Boding, Lasse Buus, Terkild B The outstanding time and expenses are then transferred directly to an invoice, increasing billing efficiency.Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif “Sage Peachtree 2011 makes it easier for small businesses to quickly get the information they need so they can focus on what they do best: running their businesses.” Sage Peachtree 2011 helps small business owners and managers: Streamline Service Billing: Businesses that provide services can quickly invoice customers for any unbilled time and expenses unbilled items can be filtered by date, customer or job. “At a time when most small businesses need to do more with less, Sage Peachtree 2011 will help them to leverage efficiencies and answer the three most important questions of their day: are business activities on track, on schedule, and within budget,” said Connie Certusi, general manager, small business accounting solutions, Sage North America.
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